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KMID : 0384320120330060346
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Korean Journal of Family Medicine
2012 Volume.33 No. 6 p.346 ~ p.355
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The Efficacy and Safety of a Combined Alendronate and Calcitriol Agent (Maxmarvil): A Postmarketing Surveillance Study in Korean Postmenopausal Women with Osteoporosis
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Suh Hee-Won
Kim Hyun-Ok
Kim Young-Sik
Sunwoo Sung
Lee Jung-Ah
Lee Hye-Ree
Kim Byung-Sung
Kim Dae-Hyun
Choi Youn-Seon
Cheong Yoo-Seock
Yum Keun-Sang
Yang Yun-Jun
Yu Byung-Yeon
Cho Chung-Hwan
Park Sat-Byul
Shin Dong-Hyeok
Korean Post-Marketing Surveillance Research Group
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Abstract
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Background: Combined therapy with alendronate and calcitriol may have additive effects on bone density. An observational study was performed to evaluate the efficacy and safety of Maxmarvil, a combinative agent of alendronate (5 mg) and calcitriol (0.5 ?g), and to identify factors associated with efficacy.
Methods: A total of 568 postmenopausal women with osteoporosis were enrolled by family physicians in 12 hospitals. The study subjects took Maxmarvil daily for 12 months. Questionnaires about baseline characteristics, socioeconomic status, and daily calcium intake were completed at the first visit. Adverse events were recorded every 3 months and bone mineral density (BMD) in the lumbar spine was measured using dual-energy X-ray absorptiometry at baseline and after 12 months. We evaluated the efficacy and safety of Maxmarvil, and the factors related to BMD improvement.
Results: A total of 370 patients were included in final analysis. The median BMD was 0.81 ± 0.12 g/cm2 at pre-treatment and 0.84 ± 0.13 g/cm2 after one year. The average BMD improvement was 3.4% ± 6.4% (P < 0.05), and 167 (45.1%) patients showed improvement. Factors associated with improved BMD were continuation of treatment (odds ratio [OR], 2.41; 95% confidence interval [CI], 1.15 to 5.07) and good compliance (OR, 2.54; 95% CI, 1.29 to 5.00). Adverse events were reported by 35 of the 568 patients, with the most common being abdominal pain and dyspepsia.
Conclusion: Maxmarvil was found to be safe, well tolerated and effective in osteoporosis treatment. Continuation of treatment and good compliance were the factors associated with efficacy.
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KEYWORD
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Alendronate, Calcitriol, Maxmarvil, Postmenopausal Osteoporosis
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